IN VITRO CELL GROWTH-INHIBITING AND IMMUNE MODULATING EFFECTS OF HEAT-SENSITIVE BIOACTIVE SUBSTANCES ISOLATED FROM PARASITE AND INFECTED HOST TISSUES AFTER EXPERIMENTAL TRICHINELLOSIS

Authors

  • Neli Tsocheva-Gaytandzhieva Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Svetlozara Petkova Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Elena Nikolova Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Reneta Toshkova Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Margarita Gabrashanska Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Ivelin Vladov Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Veselin Nanev Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria
  • Valeria Dilcheva Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria

DOI:

https://doi.org/10.5281/zenodo.2596711

Keywords:

experimental trichinellosis, heat-sensitive bioactive substances, antiproliferative and immune modulating activities, lymphocytes, bone marrow cells, in vitro

Abstract

Antiproliferative effects of biochemically isolated from Trichinella spiralis muscle larvae, livers and spleens from healthy and T. spiralis infected rats heat-sensitive bioactive substances (HSBSes) were studied in vitro on nonactivated and mitogen activated with phytohemagglutinin (PHA) lymphocytes and bone marrow precursor cells. Stronger antiproliferative effects were established for HSBSes from parasite and infected host tissues than from healthy rats. Stronger growth inhibiting and immune modulating activities of HSBSes were determined on PHA activated lymphocytes. Also antiproliferative effects were established on bone marrow precursor cells. This probably was a result of changed liver metabolism and immunity in T. spiralis infected hosts.

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Published

2019-06-27

How to Cite

Tsocheva-Gaytandzhieva, N., Petkova, S., Nikolova, E., Toshkova, R., Gabrashanska, M., Vladov, I., … Dilcheva, V. (2019). IN VITRO CELL GROWTH-INHIBITING AND IMMUNE MODULATING EFFECTS OF HEAT-SENSITIVE BIOACTIVE SUBSTANCES ISOLATED FROM PARASITE AND INFECTED HOST TISSUES AFTER EXPERIMENTAL TRICHINELLOSIS. TRADITION AND MODERNITY IN VETERINARY MEDICINE, 4(1), 39–45. https://doi.org/10.5281/zenodo.2596711

Issue

Vol. 4 No. 1 (2019): Volume 4 Issue 1 (2019)

Section

Articles

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Copyright (c) 2019 TRADITION AND MODERNITY IN VETERINARY MEDICINE

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This work is licensed under a Creative Commons Attribution 4.0 International License.